Structural basis for a pH-sensitive calcium leak across membranes
نویسندگان
چکیده
منابع مشابه
Structural basis for a pH-sensitive calcium leak across membranes.
Calcium homeostasis balances passive calcium leak and active calcium uptake. Human Bax inhibitor-1 (hBI-1) is an antiapoptotic protein that mediates a calcium leak and is representative of a highly conserved and widely distributed family, the transmembrane Bax inhibitor motif (TMBIM) proteins. Here, we present crystal structures of a bacterial homolog and characterize its calcium leak activity....
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Two-pore domain K channels encoded by genes KCNK1-17 (K2p1-17) play important roles in regulating cell excitability. We report here that rat taste receptor cells (TRCs) highly express TASK-2 (KCNK5; K2p5.1) and to a much lesser extent TALK-1 (KCNK16; K2p16.1) and TASK-1 (KCNK3; K2p3.1) and suggest potentially important roles for these channels in setting resting membrane potentials and in sour ...
متن کاملTaste receptor cells express pH-sensitive leak K+ channels.
Two-pore domain K+ channels encoded by genes KCNK1-17 (K2p1-17) play important roles in regulating cell excitability. We report here that rat taste receptor cells (TRCs) highly express TASK-2 (KCNK5; K2p5.1), and to a much lesser extent TALK-1 (KCNK16; K2p16.1) and TASK-1 (KCNK3; K2p3.1), and suggest potentially important roles for these channels in setting resting membrane potentials and in so...
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Calmodulin is a prototypical and versatile Ca(2+) sensor with EF hands as its high-affinity Ca(2+) binding domains. Calmodulin is present in all eukaryotic cells, mediating Ca(2+)-dependent signaling. Upon binding Ca(2+), calmodulin changes its conformation to form complexes with a diverse array of target proteins. Despite a wealth of knowledge on calmodulin, little is known on how target prote...
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The cytoplasmic pH value o f guard cells o f Valerianella locusta was determined from the distribution o f the weak acid [l4C]ABA between the medium and the cell, which was shown to be 8.1 ±0.1. Treatment o f guard cells in media with low pH (pH 5.0) and different concentra tions o f sodium acetate (0 -5 m o lm '3) caused a considerable acidification o f the cytoplasm (6 .6-7 .7). Using the co...
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ژورنال
عنوان ژورنال: Science
سال: 2014
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.1252043